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SFC / SFE Systems


The SF-4000 series of reliable SFC systems will give you increased productivity in both chiral and achiral chromatography, from simple analytical separations for routine analyisis and method development through to preparative systems at scales using from 1cm to 3cm ID columns.

Analytical SFC-01

Analytical SFC

The JASCO SF-4000 integrated Analytical SFC system has been developed for routine separation to method development

Semi Prep SFC-01

Semi-Prep SFC

SP-4000 Semi-prep hybrid SFC system crosses the divide between analytical and prep SFC

Prep SFC-01

Prep SFC

The PR-4088 Prep SFC system is designed for large scale purifications

Supercritical Fluid Extraction-01

Supercritical Fluid Extraction

4000 series Supercritical fluid extraction (SFE) for analytical to liter scale material extraction.

Fuel Analysis SFC-01

Fuel Analysis by SFC-FID

The fully automated SFC-FID system, fast and accurate petrochemical analysis.



The use of supercritical fluids offers a green alternative to traditional HPLC with the use of CO2 in place of organic solvents. This reduction offers cost, health, and safety benefits, as well as faster, cleaner sample recovery during material purification. Other advantages of supercritical fluids include the liquid-like densities, for higher solubility and increased column loading. The low viscosity and highly diffusion lead to faster separations and faster extractions.

SFC has long been the method of choice for chiral separations, but with the large range (and growing rapidly) of column phases available – SFC is now becoming a powerful tool for achiral separations, both analytically and for sample prep.

JASCO SFC System Advantage


JASCO has been developing packed column SFC and SFE systems for more than 30 years; the continual development process has resulted in the new 4000 series being even more user friendly, robust and productive.

Patented High-Speed Regulator

The 4000 series high-speed dynamic back-pressure regulator ensures that a constant back pressure is maintained at all times, regardless of the flow rate and with virtually no hysteresis. The extremely low dead volume prevents fractions from remixing and prevents precipitation build-up in the flow line.

Wide Range of Detectors

Single wavelength UV-visible, PDA and the CD-4095 the only chiral detector suitable for SFC. Non-optical detectors include FID, ELSD and single-quad mass-spec.


All 4000 series SFC systems can be used for HPLC, simply switch off the cooling and BPR.

Integrated Modular System

The basic system for each scale can be adapted to suit your application. From modifier selection to column heater type to detector combinations.


JASCO SFC systems are compatible with most Mass Spectrometers and offer direct control in both Thermo Xcalibur and Sciex Analyst software.

Unparalleled Customer Service

JASCO provides professional, fast and courteous support on all of our products. We have service centers strategically located throughout the U.S. to ensure the highest level of customer satisfaction. Our scheduled and on-site training classes are available for advanced application training.

Multiple Configurations

JASCO offers multiple configurations, please contact us to discuss your requirements in detail. 

Benefits of using SFC Systems for Separation

High Solubility & Low Viscosity

Greater solubility and lower viscosity than liquid phase HPLC leading to rapid column equilibration, faster separations and higher productivity.

Wide Molecular Structure Coverage

Applicable to a wide range of molecular structures with a wide range of polarities from strongly hydrophobic to strongly hydrophilic.


SFC uses simple separation solvents, generally CO2 with alcoholic modifiers, which are much greener than other solvents generally used in NPLC and RPLC.


Dramatic reduction in solvent costs for both purchase and disposal.

Straightforward Operation

SFC scales-up from analytical to preparative with ease, so method development for high quality chiral and achiral sample purification with low solvent contamination is completely straightforward.

Request Information

Call us for more information on 0800 773 274 or email or simply use the contact form below and one of our technical specialists will contact you directly to discuss your needs.

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